Destination Void

The starship Earthling, filled with thousands of hybernating colonists en route to a new world at Tau Ceti, is stranded beyond the solar system when the ship's three Organic Mental Cores, disembodied human brains that control the vessel's functions, go insane. An emergency skeleton crew sees only one chance for survival: to create an artificial consciousness in the Earthling's primary computer, which could guide them to their destination . . . or could destroy the human race.
Frank Herbert's classic novel that begins the epic Pandora Sequence (written with Bill Ransom), which also includes The Jesus Incident, The Lazarus Effect, and The Ascension Factor.